Sulbactam Cefoperazone Injection

Description

Zostum 1.5g is a combination antibiotic medication containing Sulbactam and Cefoperazone. It is used for treating a variety of bacterial infections. Each vial contains 1.5 grams of the active ingredients, usually comprising 1 gram of Cefoperazone and 0.5 grams of Sulbactam.

Uses of Zostum 1.5g

• Treatment of Bacterial Infections: Zostum 1.5g is used to treat infections caused by susceptible bacteria, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, abdominal infections, and infections in neutropenic patients.

How Zostum 1.5g Works

Zostum 1.5g combines the effects of two antibiotics:

• Cefoperazone: A third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis, leading to cell lysis and death.
• Sulbactam: A beta-lactamase inhibitor that prevents the breakdown of Cefoperazone by beta-lactamase enzymes produced by resistant bacteria, thereby extending the antibiotic spectrum of Cefoperazone.

Benefits of Zostum 1.5g

• Broad-Spectrum Antibiotic: Effective against a wide range of Gram-positive and Gram-negative bacteria.
• Enhanced Efficacy: The combination of Cefoperazone and Sulbactam helps overcome antibiotic resistance by inhibiting beta-lactamase enzymes.

Side Effects of Zostum 1.5g

Most side effects are mild and temporary. However, consult your doctor if they persist or cause concern.

Common Side Effects:

• Diarrhea
• Nausea
• Vomiting
• Pain or swelling at the injection site
• Rash

Serious Side Effects (rare):

• Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
• Severe gastrointestinal conditions (e.g., pseudomembranous colitis)
• Blood disorders (e.g., thrombocytopenia, neutropenia)

How to Use Zostum 1.5g

• Administration: Zostum 1.5g is administered via intravenous (IV) or intramuscular (IM) injection. The dosage and duration depend on the type and severity of the infection, as well as the patient’s age, weight, and kidney function.
• Preparation: Follow the instructions provided by the healthcare provider for reconstituting the injection. Ensure the solution is clear and free from particles before administration.
• Dosage: The typical adult dosage ranges from 2 to 4 grams per day, divided into doses every 12 hours. The exact dosage and frequency will be determined by the doctor.

Patient Advice

• Adherence: Follow the prescribed dosage schedule strictly and complete the full course of treatment, even if you feel better.
• Hydration: Drink plenty of fluids unless advised otherwise by your doctor.
• Report Side Effects: Inform your doctor immediately if you experience severe side effects or signs of an allergic reaction.

Precautions

• Medical History: Inform your doctor if you have a history of kidney or liver disease, gastrointestinal disease (especially colitis), or any known allergies.
• Pregnancy and Breastfeeding: Consult your doctor before using Zostum 1.5g if you are pregnant or breastfeeding.
• Drug Interactions: Inform your doctor about all the other medications you are taking to avoid potential interactions.
• Monitoring: Regular monitoring of kidney and liver function, as well as blood counts, may be necessary during prolonged therapy.